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ABOUT ReBone+

Support your health and beauty from within with osteocalcin,
a protein produced by the bones.

Osteocalcin is a type of bone hormone, primarily involved in bone formation and metabolism. However, recent research has revealed various benefits of osteocalcin for beauty and health. This hormone improves glucose and fat metabolism, boosts energy levels, helps maintain healthy skin, and is even expected to have anti-aging effects.

Osteocalcin (bone hormone) acts on various organs and helps maintain youthfulness throughout the body.

The Various Benefits of Osteocalcin

  • Skin

    Collagen produced by bones helps reduce wrinkles.

  • Brain

    Maintains neural connections, improving cognitive and memory functions.

  • Heart and Blood Vessels

    Maintains neural connections, improving cognitive and memory functions.

  • Liver

    Boosts stem cell metabolism, enhancing liver function.

  • Pancreas

    Promotes insulin secretion, lowering blood sugar levels.

  • Kidneys

    The hormone GF23 improves kidney function.

  • Small Intestine

    Enhances nutrient absorption, improves digestion through bacterial regulation.

  • Testes

    Increases the secretion of male hormones, improving reproductive function.

The Discovery of Osteocalcin

In 2007, Professor Gerard Karsenty from the Department of Genetics and Development at Columbia University in the United States discovered that a type of protein produced by bones acts on the pancreas to promote insulin secretion, thereby lowering blood sugar levels. That protein is "osteocalcin." Subsequent research revealed that osteocalcin activates various organs.

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To be forever young

Collagen forms the foundation of bones, and osteocalcin has a role in producing high-quality collagen. As a result, youthful elasticity is maintained. When bone density decreases, the bones of the body shrink, making a person shorter, and as facial bones shrink, gaps form between the skin and bones, causing sagging and wrinkles. Osteocalcin also neutralizes reactive oxygen species, suppresses oxidative stress that accelerates aging throughout the body, keeps blood vessels young, and increases the secretion of adiponectin, a longevity hormone that reduces fat, offering comprehensive support for youthfulness.

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Effects on Cognitive Function

In an aging society, the number of dementia patients is increasing, and it is estimated that by 2025, one in five people over the age of 65 will suffer from dementia.

This is where osteocalcin comes in—it maintains neural connections and improves memory and cognitive functions. Higher levels of osteocalcin are said to enhance the function of neurons (nerve cells), which transmit information and store memories. By activating neurons, memory and cognitive abilities improve, leading to a more comfortable daily life, not just for the individual, but for their family and friends as well.

Success in Extracting Osteocalcin for Supplements

  • We succeeded in extracting the extremely rare substance osteocalcin, which is found
  • in trace amounts in pork bones, and have made it available in supplement form.
  • By combining it with placenta, which promotes cell growth and differentiation and
  • supports regeneration and repair, we have created a solution for building a healthier,
  • more youthful body.
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